The team at UNITO

Our PI Prof. Livio Trusolino and his team at the University of Torino have been busy writing papers. The details of the five new COLOSSUS-acknowledged publications are below. Congratulations to all researchers involved!

  1. Di Nicolantonio F, Vitiello PP, Marsoni S, Siena S, Tabernero J, Trusolino L, Bernards R, Bardelli A. Precision Oncology in Metastatic Colorectal Cancer – From Biology to Medicine. Nat Rev Clin Oncol. 2021;18:506-525. doi: 10.1038/s41571-021-00495-z.
  2. Avolio M, Trusolino L. Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes. Cancer Discov. 2021;11:1644-1660. doi: 10.1158/2159-8290.CD-20-1531
  3. Pinnelli M, Trusolino L. The gRASs is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRAS G12C Inhibitors. Cancer Discov. 2021;11:1874-1876. doi: 10.1158/2159-8290.CD-21-0609.
  4. Ponsioen B, Post JB, Buissant des Amorie JR, Laskaris D, van Ineveld RL, Kersten S, Bertotti A, Sassi F, Sipieter F, Cappe B, Mertens S, Verlaan-Klink I, Boj SF, Vries RGJ, Rehmann H, Vandenabeele P, Riquet FB, Trusolino L, Bos JL, Snippert HJG. Quantifying Single-Cell ERK Dynamics in Colorectal Cancer Organoids Reveals EGFR as an Amplifier of Oncogenic MAPK Pathway Signalling. Nat Cell Biol. 2021;23:377-390. doi: 10.1038/s41556-021-00654-5.
  5. Tedesco M, Giannese F, Lazarević D, Giansanti V, Rosano D, Monzani S, Catalano I, Grassi E, Zanella ER, Botrugno OA, Morelli L, Panina Bordignon P, Caravagna G, Bertotti A, Martino G, Aldrighetti L, Pasqualato S, Trusolino L, Cittaro D, Tonon G. Chromatin Velocity Reveals Epigenetic Dynamics by Single-Cell Profiling of Heterochromatin and Euchromatin. Nat Biotechnol. 2022;40:235-244. doi: 10.1038/s41587-021-01031-1