Project Publications

COLOSSUS publications will be added here as articles are published.

  1. Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella,Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Argiles, Paolo Nuciforo, Andrea Sottoriva, Rodrigo Dienstmann, Diego Pasini, Elena GrassiClaudio Isella, Andrea Bertotti and Livio Trusolino, Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype. Science Translational Medicine  05 Aug 2020: Vol. 12, Issue 555, eaax8313 DOI: 10.1126/scitranslmed.aax8313. Repository link:
  2. Russo et al. Adaptive mutability of colorectal cancers in response to targeted therapies. Science 2019 Nov 7. pii: eaav4474. DOI: 10.1126/science.aav4474. Download the pdf here.
  3. Irene Catalano, Elena Grassi, Andrea Bertotti, Livio Trusolino, Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga, Trends in Cancer, December 2019, Vol. 5, No. 12 DOI: Download the pdf here.
  4. WH Fridman, I Miller, C Sautès-Fridman, AT Byrne, Therapeutic Targeting of the Colorectal Tumor Stroma, Gastroenterology, 14 October 2019, pii: S0016-5085(19)41442-X. DOI: 10.1053/j.gastro.2019.09.045. Download the pdf here.
  5. Elke Burgermeister, Francesca BattaglinFagr Eladly, Wen Wu, Frank Herweck , Nadine Schulte, Johannes Betge, Nicolai HärtelJakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert, Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A,  2019 Jul;45:139-154. DOI: 10.1016/j.ebiom.2019.07.004. Epub 2019 Jul 9. Download the pdf here.
  6. Irene Catalano and Livio Trusolino, The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy, Cancer Cell, Volume 36, Issue 1, 8 July 2019, Pages 1-3, DOI: 10.1016/j.ccell.2019.06.001. Embargo until 01/08/2020.
  7. Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, and Boris N. Kholodenko, Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction, Sci Rep. 2018; 8: 16217. Published online 2018 Nov 1. DOI: 10.1038/s41598-018-34353-3  Download the pdf here.
  8. O’Farrell AC, Miller IS, Evans R, Alamanou M, Cary M, Mallya Udupi G, Lafferty A, Monsefi N, Cremona M, Prehn JHM, Verheul HM, Gallagher WM, Gehrmann M, Byrne AT, Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre-Clinical Detection of Off-Target Toxicities Associated with Sunitinib Malate, 2019 Feb 15:e1800159. DOI: 10.1002/prca.201800159. Embargoed until 15 February 2020. Repository link:
  9. Florent Petitprez, Cheng-Ming Sun, Laetitia Lacroix, Catherine Sautès-Fridman, Aurélien de Reyniès and Wolf H. Fridman, Quantitative analyses of the tumor microenvironment composition and orientation in the era of precision medicine, Frontiers in Oncology, September 25, 2018, DOI: 10.3389/fonc.2018.00390. Download the pdf here.
  10. M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba’ie, A. C. O’Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne, J. H. Prehn,  Anti-angiogenic drug scheduling optimisation with application to colorectal cancer, Scientific Reports, Volume 8, Article number: 11182 (2018)DOI: 10.1038/s41598-018-29318-5  Download the pdf here.